Estradiol EP Impurity D-d3 (delta-9(11)-Estradiol-d3) CAS 791-69-5 (non-labelled)
| CAS No. | 791-69-5 (non-labelled) |
| Molecular Formula | - |
| Molecular Weight | 273.38 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Estradiol EP Impurity D-d3 (delta-9(11)-Estradiol-d3) (CAS 791-69-5 (non-labelled)) is a certified pharmaceutical impurity reference standard with the molecular formula C18H19D3O2 and a molecular weight of 273.38 g/mol.
The molecular framework of Estradiol EP Impurity D-d3 (delta-9(11)-Estradiol-d3) (C18H19D3O2) is characterized by deuterium isotope labeling, a steroid core, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C18H19D3O2 |
| Molecular Weight | 273.38 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 9.5 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
Related Estradiol Standards
- 17beta-Estradiol-13C2 (CAS 82938-05-4)
- Estradiol Impurity 22 (CAS CATO-C4X-163622)
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- Beta-Estradiol (CAS 50-28-2)
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